4-Amino(5,6-2H2)pyrimidin-2(1H)-one

Names

[ CAS No. ]:
106391-24-6

[ Name ]:
4-Amino(5,6-2H2)pyrimidin-2(1H)-one

[Synonym ]:
4-Amino(5,6-H)pyrimidin-2(1H)-one
4-Amino-2(1H)-(5,6-H)pyrimidinone
2(1H)-Pyrimidinone-5,6-d, 4-amino-

Biological Activity

[Description]:

Cytosine-d2 is the deuterium labeled Cytosine[1]. Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging[2][3].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Maxam AM, et, al. A new method for sequencing DNA. Proc Natl Acad Sci U S A. 1977 Feb;74(2):560-4.  

[3]. Oh G, et, al. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging. Nat Commun. 2018 Feb 13;9(1):644.  

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C4H3D2N3O

[ Molecular Weight ]:
113.114

[ Exact Mass ]:
113.055817

[ PSA ]:
71.77000

[ LogP ]:
-1.71

[ Index of Refraction ]:
1.689

Related Compounds