106391-24-6

106391-24-6 structure

Name: 4-Amino(5,6-2H2)pyrimidin-2(1H)-one
Chemical Name: cytosine-5,6-d2
CAS Number: 106391-24-6
Molecular Formula: C₄H₃D₂N₃O
Molecular Weight: 113.114
Catalog: Research Areas Others
Create Date: 2018-06-22 20:40:08
Modify Date: 2024-01-18 19:24:11
Cytosine-d2 is the deuterium labeled Cytosine[1]. Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging[2][3].

Name	cytosine-5,6-d2
Synonyms	4-Amino(5,6-H)pyrimidin-2(1H)-one 4-Amino-2(1H)-(5,6-H)pyrimidinone 2(1H)-Pyrimidinone-5,6-d, 4-amino-

Description	Cytosine-d2 is the deuterium labeled Cytosine[1]. Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging[2][3].
Related Catalog	Research Areas >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Maxam AM, et, al. A new method for sequencing DNA. Proc Natl Acad Sci U S A. 1977 Feb;74(2):560-4. [3]. Oh G, et, al. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging. Nat Commun. 2018 Feb 13;9(1):644.