Tempol-d17

Names

[ Name ]:
Tempol-d17

[Synonym ]:
{4-Hydroxy-2,2,6,6-tetrakis[(H)methyl](H)-1-piperidinyl}oxidanyl
4-Hydroxy-TEMPO-d17
TEMPOL-d17
4-hydroxy-2,2,6,6-tetramethylpiperidine-d17-1-oxyl
{4-Hydroxy-2,2,6,6-tetrakis[(H)methyl](H)piperidin-1-yl}oxidanyl
<2H17>4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl
1-Piperidinyl-3,3,4,5,5-d-oxy, 4-hydroxy-2,2,6,6-tetra(methyl-d)-
MFCD00190466

Biological Activity

[Description]:

Tempol-d17 is the deuterium labeled Tempol[1]. Tempol is a general superoxide dismutase (SOD)-mimetic drug that efficiently neutralizes reactive oxygen species (ROS)[2][3].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> Autophagy

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Vilar-Pereira G, et al. Resveratrol Reverses Functional Chagas Heart Disease in Mice. PLoS Pathog. 2016 Oct 27;12(10):e1005947.

[3]. Chatterjee PK, et al. Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. Kidney Int. 2000 Aug58(2):658-73.

Chemical & Physical Properties

[ Melting Point ]:
69-71ºC(lit.)

[ Molecular Formula ]:
C₉HD₁₇NO₂

[ Molecular Weight ]:
189.350

[ Exact Mass ]:
189.240463

[ PSA ]:
23.47000

[ LogP ]:
1.28370

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3