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6-Benzoylheteratisine

Names

[ CAS No. ]:
99759-48-5

[ Name ]:
6-Benzoylheteratisine

[Synonym ]:
Tri-O-acetylhesperetin
heteratizine
(S)-5,7-diacetoxy-2-(3-acetoxy-4-methoxy-phenyl)-chroman-4-one
O-benzoylheteratisine
benzoylheteratisine
Hesperetin Triacetate
(S)-5,7-Bis(acetyloxy)-2-[3-(acetyloxy)-4-methoxyphenyl]-2,3-dihydro-4H-1-benzopyran-4-one

Biological Activity

[Description]:

6-Benzoylheteratisine is a naturally occurring antagonist of the Na+ channel activator aconitine[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Research Areas >> Neurological Disease

[In Vitro]

6-Benzoylheteratisine (3 μM) decreases the amplitude of the presynaptic fiber spike at all stimulus intensities tested and shiftes the curve to the right[1]. 6-benzoylheteratisine is capable of inhibiting stimulus-triggered epileptiform activity recorded in CA1 stratum pyramidale[1].

[References]

[1]. A Ameri, et al. Interaction of the structurally related aconitum alkaloids, aconitine and 6-benzyolheteratisine, in the rat hippocampus. Eur J Pharmacol. 1999 Dec 15;386(2-3):187-94.

Chemical & Physical Properties

[ Density]:
1.32g/cm3

[ Boiling Point ]:
645.9ºC at 760 mmHg

[ Molecular Formula ]:
C29H37NO6

[ Molecular Weight ]:
495.60700

[ Flash Point ]:
344.4ºC

[ Exact Mass ]:
495.26200

[ PSA ]:
85.30000

[ LogP ]:
2.98790

[ Index of Refraction ]:
1.622

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Related Compounds