metaphit methanesulfonate

Names

[ CAS No. ]:
99287-12-4

[ Name ]:
metaphit methanesulfonate

Chemical & Physical Properties

[ Boiling Point ]:
433.7ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₈N₂O₃S₂

[ Molecular Weight ]:
396.56700

[ Flash Point ]:
216.1ºC

[ Exact Mass ]:
396.15400

[ PSA ]:
110.44000

[ LogP ]:
5.58890

[ Appearance of Characters ]:
solid | white

[ Storage condition ]:
−20°C

[ Stability ]:
Hygroscopic

[ Water Solubility ]:
H2O: soluble

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Acylation of sigma receptors by Metaphit, an isothiocyanate derivative of phencyclidine.

Eur. J. Pharmacol. 161 , 273-277, (1989)

Pretreatment of guinea pig brain membranes with 1-[1-(3-isothiocyanatophenyl)cyclohexyl]piperidine (Metaphit) caused irreversible and differential inhibition of ligand binding to sigma (sigma) recepto...

Metaphit, a proposed phencyclidine (PCP) antagonist, prevents PCP-induced locomotor behavior through mechanisms unrelated to specific blockade of PCP receptors.

Eur. J. Pharmacol. 140 , 267, (1987)

Metaphit, a derivative of phencyclidine (PCP) which irreversibly binds to a population of PCP receptor sites in rat brain, has been considered as a potentially specific PCP antagonist. In whole animal...

Long-term blockade of the dopamine uptake complex by metaphit, an isothiocyanate derivative of phencyclidine.

Synapse 3 , 239-245, (1989)

[3H]Mazindol was used to label the dopamine uptake complex in mouse striatum in vitro in the presence and absence of metaphit, an isothiocyanate derivative of phencyclidine. In some experiments, metap...