Metaphit

Names

[ Name ]:
Metaphit

Biological Activity

[Description]:

Metaphit is a specific PCPantagonist and site-directed acylating agent of the [3H]phencyclidine binding site in rat brain homogenates[1]. Metaphit prevents PCP-induced locomotor behavior through presynaptic mechanisms[2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. E D French, et al. Metaphit, a proposed phencyclidine (PCP) antagonist, prevents PCP-induced locomotor behavior through mechanisms unrelated to specific blockade of PCP receptors. Eur J Pharmacol. 1987 Aug 21;140(3):267-74

[2]. M F Rafferty, et al. A specific acylating agent for the [3H]phencyclidine receptors in rat brain. FEBS Lett. 1985 Feb 25;181(2):318-22.

Chemical & Physical Properties

[ Density]:
1.12g/cm3

[ Boiling Point ]:
433.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₈H₂₄N₂S

[ Molecular Weight ]:
300.46

[ Flash Point ]:
216.1ºC

[ Exact Mass ]:
396.15400

[ PSA ]:
110.44000

[ LogP ]:
5.58890

Related Compounds

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