(S)-(-)-Bay K 8644

Names

[ Name ]:
(S)-(-)-Bay K 8644

[Synonym ]:
Tocris-1544
(S)-(-)-Bay K8644
Lopac-B-112
S-(-)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
Bay-K-8644 ((S)-(-)-)

Biological Activity

[Description]:

Bay-K-8644 (S)-(-)- is an agonist of L-type Ca2+ channel. Bay-K-8644 (S)-(-)- activates Ba2+ currents (IBa) (EC50=32 nM).

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Research Areas >> Cardiovascular Disease

[Target]

EC50: 32 nM (IBa)[1]

[In Vitro]

(±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa (R(+)-Bay K 8644 as an antagonist and Bay-K-8644 (S)-(-)- as an agonist. Bay-K-8644 (S)-(-)- can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in gastric myocytes of the guinea pig antrum[1]. The Ca2+ channel activity is enhanced by 3–30 μM Bay-K-8644 (S)-(-)-, an agonist of L-type Ca2+ channels[2]. The interactions of two Ca2+ channel activators Bay-K-8644 (S)-(-)- and FPL 64176 is examined on smooth muscle L-type Ca2+ channels. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by Bay-K-8644 (S)-(-)- (EC50=14 nM). Bay-K-8644 (S)-(-)- (100 nM) increases whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176[3].

[References]

[1]. Zhu HL, et al. Antagonistic actions of S(-)-Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba(2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):609-15.

[2]. Mironov SL, et al. L-type Ca2+ channels in inspiratory neurones of mice and their modulation by hypoxia. J Physiol. 1998 Oct 1;512 ( Pt 1):75-87.

[3]. Rampe D, et al. Functional interactions between two Ca2+ channel activators, (S)-Bay K 8644 and FPL 64176, in smooth muscle. Mol Pharmacol. 1992 Apr;41(4):599-602.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.37g/cm3

[ Boiling Point ]:
429.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₆H₁₅F₃N₂O₄

[ Molecular Weight ]:
356.29700

[ Flash Point ]:
213.4ºC

[ Exact Mass ]:
356.09800

[ PSA ]:
84.15000

[ LogP ]:
4.19940

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ RIDADR ]:
NONH for all modes of transport

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Related Compounds

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