Raclopride tartrate

Names

[ Name ]:
Raclopride tartrate

[Synonym ]:
(S)-2-[(3,5-dichloro-6-methoxy-2-hydroxybenzamido)methyl]-1-ethylpyrrolidine L-tartrate
raclopride tartarate
raclopride tartrate
(S)-2-[(3,5-dichloro-6-methoxy-2-hydroxybenzamido)methyl]-1-ethylpyrrolidine L-tartrate
S(-)-RACLOPRIDE (+)-TARTRATE SALT

Biological Activity

[Description]:

Raclopride tartrate is a selective dopamine D2/D3 receptor antagonist with potential antipsychotic effects. Raclopride tartrate binds to D2 and D3 receptors with Kis of 1.8 nM and 3.5 nM, respectively[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[Target]

D2 Receptor:1.8 nM (Ki)

D3 Receptor:3.5 nM (Ki)

D4 Receptor:2400 nM (Ki)

D1 Receptor:18000 nM (Ki)

[In Vivo]

Raclopride tartrate (0.1, 0.3, or 0.6 mg/kg; IP; 30 min; albino male mice of the OF1 strain) significantly reduces time allocated to attack behavior[2].

[References]

[1]. Seeman P, et al. Dopamine receptor pharmacology. Trends Pharmacol Sci. 1994;15(7):264-270.

[2]. Aguilar MA, et al. Behavioral profile of raclopride in agonistic encounters between male mice. Pharmacol Biochem Behav. 1994;47(3):753-756.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₆Cl₂N₂O₉

[ Molecular Weight ]:
497.32400

[ Exact Mass ]:
496.10200

[ PSA ]:
176.86000

[ LogP ]:
1.12790

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
CV3465000

Articles

Effect of raclopride on dopamine D2 receptor mRNA expression in rat brain.

Neuroscience 47 , 771-779, (1992)

Prolonged treatment with dopamine D2 receptor antagonists is known to elevate the density of dopamine D2 receptor binding sites in caudate-putamen and nucleus accumbens in rat and human brain. In this...

Chronic treatment with the D1 receptor antagonist, SCH 23390, and the D2 receptor antagonist, raclopride, in cebus monkeys withdrawn from previous haloperidol treatment. Extrapyramidal syndromes and dopaminergic supersensitivity.

Psychopharmacology 112 , 389-397, (1993)

The effects of chronic treatment with dopamine (DA) D1 and D2 receptor antagonists were evaluated in eight cebus apella monkeys with mild oral dyskinesia after previous haloperidol treatment. SCH 2339...

Dopamine receptor antagonist properties of S 14506, 8-OH-DPAT, raclopride and clozapine in rodents.

Eur. J. Pharmacol. 271 , 167, (1994)

S 14506 (1-[-(4-fluorobenzoylamino)ethyl]-4-(7-methoxynaphthyl)piper azine hydrochloride), 8-OH-DPAT ((+/-)-8-hydroxydipropylaminotetralin hydrobromide), clozapine and raclopride were compared in some...