Picfeltarraenin IB

Names

[ Name ]:
Picfeltarraenin IB

[Synonym ]:
(1R,4R,9β,16α)-16-Hydroxy-9,10,14-trimethyl-11,22-dioxo-20,24-epoxy-4,9-cyclo-9,10-secocholesta-5,23-dien-1-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside
(1R,4R,9β,16α)-16-Hydroxy-9,10,14-trimethyl-11,22-dioxo-21,24-epoxy-4,9-cyclo-9,10-secocholesta-5,23-dien-1-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside
19-Norlanosta-5,23-diene-11,22-dione, 3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-20,24-epoxy-16-hydroxy-9-methyl-, (3α,9β,10α,16α)-
Estr-5-en-11-one, 3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-17-[(3R)-3,4-dihydro-6-(1-methylethyl)-4-oxo-2H-pyran-3-yl]-16-hydroxy-4,4,9,14-tetramethyl-, (3α,9β,10alph ; a,16α,17β)-
estr-5-en-11-one, 3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-17-[(2R)-2,3-dihydro-2-methyl-5-(1-methylethyl)-3-oxo-2-furanyl]-16-hydroxy-4,4,9,14-tetramethyl-, (3α,9β,10α,16α,17β)-
Estr-5-en-11-one, 3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-17-[(2R)-2,3-dihydro-2-methyl-5-(1-methylethyl)-3-oxo-2-furanyl]-16-hydroxy-4,4,9,14-tetramethyl-, (3α,9β,1 ; 0α,16α,17β)-

Biological Activity

[Description]:

Picfeltarraenin IB, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IB can be used for the treatment of herpes infections, cancer and inflammation[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

AChE[1]

[References]

[1]. Wen L, et al. Bioassay- and liquid chromatography/mass spectrometry-guided acetylcholinesterase inhibitors from Picriafel-terrae. Pharmacogn Mag. 2013 Oct;9(Suppl 1):S25-31.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
895.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₂H₆₄O₁₄

[ Molecular Weight ]:
792.949

[ Flash Point ]:
264.0±27.8 °C

[ Exact Mass ]:
792.429626

[ PSA ]:
221.90000

[ LogP ]:
5.14

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.607

Related Compounds

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