Picfeltarraenin IA

Names

[ Name ]:
Picfeltarraenin IA

[Synonym ]:
(1R,4R,9β,16α,17ξ)-16-Hydroxy-9,10,14-trimethyl-11,22-dioxo-20,24-epoxy-4,9-cyclo-9,10-secocholesta-5,23-dien-1-yl 2-O-(6-deoxyhexopyranosyl)pentopyranoside
(1R,4R,9β,16α)-16-Hydroxy-9,10,14-trimethyl-11,22-dioxo-21,24-epoxy-4,9-cyclo-9,10-secocholesta-5,23-dien-1-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-xylopyranoside
Picfeltarraenin IA
Estr-5-en-11-one, 3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-xylopyranosyl]oxy]-17-[(3R)-3,4-dihydro-6-(1-methylethyl)-4-oxo-2H-pyran-3-yl]-16-hydroxy-4,4,9,14-tetramethyl-, (3α,9β,10α 
,16α,17β)-
Estr-5-en-11-one, 3-[[2-O-(6-deoxyhexopyranosyl)pentopyranosyl]oxy]-17-[(2R)-2,3-dihydro-2-methyl-5-(1-methylethyl)-3-oxo-2-furanyl]-16-hydroxy-4,4,9,14-tetramethyl-, (3α,9β,10α,16α)-

Biological Activity

[Description]:

Picfeltarraenin IA, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IA can be used for the treatment of herpes infections, cancer and inflammation[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

AChE[1]

[References]

[1]. Wen L, et al. Bioassay- and liquid chromatography/mass spectrometry-guided acetylcholinesterase inhibitors from Picriafel-terrae. Pharmacogn Mag. 2013 Oct;9(Suppl 1):S25-31.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
861.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₁H₆₂O₁₃

[ Molecular Weight ]:
762.923

[ Flash Point ]:
255.3±27.8 °C

[ Exact Mass ]:
762.419067

[ PSA ]:
201.67000

[ LogP ]:
5.05

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.601

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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