Artanin

Names

[ Name ]:
Artanin

[Synonym ]:
5,7-Dimethoxy-8-[(3-methyl-2-buten-1-yl)oxy]-2H-chromen-2-one
2H-1-Benzopyran-2-one, 5,7-dimethoxy-8-[(3-methyl-2-buten-1-yl)oxy]-

Biological Activity

[Description]:

Artanin is a coumarin, has biological activities related to Alzheimer’s disease. Artanin exerts function including AChE inhibitory and AChE- and self-induced amyloid beta (Aβ) aggregation inhibitory activities, with IC50s of 51 μM, 98 μM, and 124 μM, respectively[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

AChE:51 μM (IC50)

[References]

[1]. Takomthong P, et al. Structure-Activity Analysis and Molecular Docking Studies of Coumarins from Toddalia asiatica as Multifunctional Agents for Alzheimer's Disease. Biomedicines. 2020 May 2;8(5):107.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
460.5±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₈O₅

[ Molecular Weight ]:
290.311

[ Flash Point ]:
204.9±28.8 °C

[ Exact Mass ]:
290.115417

[ PSA ]:
57.90000

[ LogP ]:
4.26

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.542

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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