Indatraline hydrochloride

Names

[ Name ]:
Indatraline hydrochloride

[Synonym ]:
lu 19-005

Biological Activity

[Description]:

Indatraline hydrochloride (Lu 19-005) is a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine) with efficacy similar to cocaine. Indatraline hydrochloride can be used for the research of antidepressive. Indatraline hydrochloride induces autophagy while simultaneously inhibiting cell proliferation. Indatraline hydrochloride may also serve to direct the development of new agents for autophagy-related diseases such as atherosclerosis or restenosis[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Dopamine Transporter

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter

[Target]

monoamine transporter[1]

[In Vitro]

Indatraline (0~5 μM; 24 hours; EGFP-LC3 stable cells) hydrochloride makes the concentration-dependent conversion of LC3[1]. Indatraline (1~10 μM; 24 hours; HeLa cells) hydrochloride makes EGFP-LC3 fluorescent vacuoles increased concentration-dependently in the cytoplasm[1]. Indatraline (1~20 μM; smooth muscle cells) hydrochloride inhibits smooth muscle cells proliferation with an IC50 of 15 μM. Indatraline hydrochloride induces autophagy in cells. Indatraline hydrochloride affects AMPK/mTOR/S6K signaling axis[1]. Western Blot Analysis[1] Cell Line: HeLa cells Concentration: 0~5 μM Incubation Time: 24 hours Result: Made the concentration-dependent conversion of LC3. Immunofluorescence[1] Cell Line: EGFP-LC3 stable cells Concentration: 1~10 μM Incubation Time: 24 hours Result: EGFP-LC3 fluorescent vacuoles increased concentration-dependently in the cytoplasm.

[In Vivo]

Indatraline (2 μM) hydrochloride inhibits neointimal accumulation of smooth muscle cells[1].

[References]

[1]. Cho YS, et al. Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway. Sci Rep. 2016; 6:34655.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₆Cl₃N

[ Molecular Weight ]:
328.66400

[ Exact Mass ]:
327.03500

[ PSA ]:
12.03000

[ LogP ]:
5.98240

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H400

[ Precautionary Statements ]:
P273

[ Personal Protective Equipment ]:
Gloves

[ Hazard Codes ]:
N: Dangerous for the environment;

[ Risk Phrases ]:
50/53

[ Safety Phrases ]:
60-61

[ RIDADR ]:
UN 3077 9/PG 3

Articles

Effects of the long-acting monoamine reuptake inhibitor indatraline on cocaine self-administration in rhesus monkeys.

J. Pharmacol. Exp. Ther. 291 , 60-69, (1999)

Cocaine is a nonselective monoamine reuptake inhibitor that is widely abused. Useful pharmacotherapies for cocaine dependence may include substitution medications that produce cocaine-like effects but...

Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline, and serotonin.

J. Neurochem. 44 , 1615-1622, (1985)

The neurochemical profile of a new compound, Lu 19-005 [(+/-)trans-3-(3,4-dichlorophenyl)-N-methyl-1-indanamine hydrochloride], has been investigated. Lu 19-005 is a potent inhibitor of the synaptosom...

Pharmacology in vivo of the phenylindan derivative, Lu 19-005, a new potent inhibitor of dopamine, noradrenaline and 5-hydroxytryptamine uptake in rat brain.

Naunyn Schmiedebergs Arch. Pharmacol. 329 , 101-107, (1985)

Behavioural effects on dopaminergic transmission of a phenylindane derivative, Lu 19-005 [(+/-)-trans-3-(3,4-dichlorophenyl)-N-methyl-l-indanamine, HCI], with potent inhibitory effect on dopamine (DA)...

Related Compounds

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