Sulfaethoxypyridazine

Names

[ CAS No. ]:
963-14-4

[ Name ]:
Sulfaethoxypyridazine

[Synonym ]:
Cysul
EINECS 213-514-7
3-Sulfanilylamino-6-aethoxy-pyridazin
6-Aethoxy-3-sulfanilamino-pyridazin
SULFAETHOXYPYRIDAZINE

Biological Activity

[Description]:

Sulfaethoxypyridazine is a sulfonamide antibacterial agent. Sulfaethoxypyridazine is a sulfonamide that is used in veterinary medicine as feedstuffs[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Antibacterial[1]

[In Vivo]

Feeding of Sulfaethoxypyridazine, a long-acting sulfonamide, to rats at dietary levels of 800, 1600, and 3200 ppm resulted in the development of characteristic lens opacities by 23 weeks. Daily oral administration of 30, 67, and 150 mg/kg to dogs resulted in the development of similar cataracts by 14 weeks[1].

[References]

[1]. Ribelin WE, et al. Development of cataracts in dogs and rats from prolonged feeding of sulfaethoxypyridazine. Toxicol Appl Pharmacol. 1967 May;10(3):557-64.

Chemical & Physical Properties

[ Density]:
1.416g/cm3

[ Boiling Point ]:
565.9ºC at 760mmHg

[ Melting Point ]:
182-184ºC

[ Molecular Formula ]:
C₁₂H₁₄N₄O₃S

[ Molecular Weight ]:
294.33000

[ Flash Point ]:
296ºC

[ Exact Mass ]:
294.07900

[ PSA ]:
115.58000

[ LogP ]:
2.99330

[ Index of Refraction ]:
1.632

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WO9410000

CHEMICAL NAME :: Sulfanilamide, N(sup 1)-(6-ethoxy-3-pyridazinyl)-

CAS REGISTRY NUMBER :: 963-14-4

BEILSTEIN REFERENCE NO. :: 0286161

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H14-N4-O3-S

MOLECULAR WEIGHT :: 294.36

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16240 mg/kg/29W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Endocrine - changes in pituitary weight Endocrine - changes in thyroid weight

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 10,557,1967

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 30450 mg/kg/29W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Endocrine - changes in thyroid weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 10,557,1967

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
WO9410000

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

Analysis of sulfonamides, trimethoprim, fluoroquinolones, quinolones, triphenylmethane dyes and methyltestosterone in fish and shrimp using liquid chromatography-mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 972 , 38-47, (2014)

A liquid chromatography-tandem mass spectrometry (LC-MS/MS) screening method is described for the detection and identification of 26 veterinary drugs in fish and other aquaculture products. The analyt...