2-(2-Propyn-1-yl)octanoic acid

Names

[ Name ]:
2-(2-Propyn-1-yl)octanoic acid

[Synonym ]:
2-(Prop-2-yn-1-yl)octanoic acid
Octanoic acid, 2-(2-propyn-1-yl)-
2-prop-2-ynyloctanoic acid
2-(2-Propyn-1-yl)octanoic acid

Biological Activity

[Description]:

2-Hexyl-4-pentynoic acid ((±)-2-Hexyl-4-pentynoic acid), valproic acid (VPA) derivative, exhibits potential roles of HDAC inhibition (IC50=13 µM) and HSP70 induction. Potent neuroprotective effects. 2-Hexyl-4-pentynoic acid causes histone hyperacetylation and protect against glutamate-induced excitotoxicity in cultured neurons[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> HSP

Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Research Areas >> Neurological Disease

Signaling Pathways >> Epigenetics >> HDAC

[References]

[1]. Yan Leng, et al. Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction. Neurosci Lett. 2010 Jun 7;476(3):127-32.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
287.1±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₈O₂

[ Molecular Weight ]:
182.259

[ Flash Point ]:
138.7±17.3 °C

[ Exact Mass ]:
182.130676

[ PSA ]:
37.30000

[ LogP ]:
3.43

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.467

MSDS

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Safety Information

[ Hazard Codes ]:
Xn

[ HS Code ]:
2916190090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916190090

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%