1,3-Dimethylurea
Names
[ CAS No. ]:
96-31-1
[ Name ]:
1,3-Dimethylurea
[Synonym ]:
Urea,N,N'-dimethyl
1,3-dimethyl urea
Symmetric dimethylurea
N,N′-dimethyl urea
Urea, 1,3-dimethyl-
N,N'-Dimethylharnstoff [German]
N,N'-Dimethylurea
UNII-WAM6DR9I4X
4-04-00-00207 (Beilstein Handbook Reference)
EINECS 202-498-7
Urea, N,N'-dimethyl-
N,N'-Dimethylharnstoff
sym-Dimethylurea
N,N`-Dimethylurea
N,N′-dimethylurea
MeNHNCONHMe
Urea,1,3-dimethyl
dimethylurea
MFCD00008286
1,3-Dimethylurea
N,N'-dimethyl-urea
Chemical & Physical Properties
[ Density]:
0.9±0.1 g/cm3
[ Boiling Point ]:
269.0±0.0 °C at 760 mmHg
[ Melting Point ]:
101-104 °C(lit.)
[ Molecular Formula ]:
C3H8N2O
[ Molecular Weight ]:
88.108
[ Flash Point ]:
124.3±18.9 °C
[ Exact Mass ]:
88.063660
[ PSA ]:
41.13000
[ LogP ]:
-1.01
[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.414
[ Storage condition ]:
Store at RT.
[ Water Solubility ]:
765 g/L (21.5 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YS9868000
- CHEMICAL NAME :
- Urea, 1,3-dimethyl-
- CAS REGISTRY NUMBER :
- 96-31-1
- BEILSTEIN REFERENCE NO. :
- 1740672
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C3-H8-N2-O
- MOLECULAR WEIGHT :
- 88.13
- WISWESSER LINE NOTATION :
- 1MVM1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4962 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2 gm/kg
- SEX/DURATION :
- female 12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2 gm/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2 gm/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 40 mmol/L
- REFERENCE :
- PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 79,1171,1982
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Risk Phrases ]:
R62
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
1
[ RTECS ]:
YS9868000
[ HS Code ]:
29241900
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Preparation
Customs
[ HS Code ]: 2924199090
[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Am. J. Physiol. Gastrointest. Liver Physiol. 298(3) , G345-51, (2010)
Facilitative UT-B urea transporters enable the passage of urea across cell membranes. Gastrointestinal urea transporters are thought to play a significant role in the urea nitrogen salvaging process t...
In vitro stimulation by paraquat of reactive oxygen-mediated lipid peroxidation in rat lung microsomes.Toxicol. Appl. Pharmacol. 60(2) , 279-86, (1981)
Novel bUT-B2 urea transporter isoform is constitutively activated.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 297(2) , R323-9, (2009)
Our previous studies have detailed a novel facilitative UT-B urea transporter isoform, bUT-B2. Despite the existence of mouse and human orthologs, the functional characteristics of UT-B2 remain undefi...