Trimidox

Names

[ Name ]:
Trimidox

[Synonym ]:
2,5-Cyclohexadien-1-one, 4-[amino(hydroxyamino)methylene]-2,6-dihydroxy-
Trimidox
Benzenecarboximidamide,N,3,4,5-tetrahydroxy
N,3,4,5-TETRAHYDROXY-BENZENECARBOXIMIDAMIDE
4-[Amino(hydroxyamino)methylene]-2,6-dihydroxy-2,5-cyclohexadien-1-one
Benzenecarboximidamide, N,3,4,5-tetrahydroxy-
3,4,5-Trihydroxybenzamidoxime
N,3,4,5-Tetrahydroxybenzenecarboximidamide

Biological Activity

[Description]:

Trimidox (VF-233) is a ribonucleotide reductase inhibitor with antileukemic activities. Trimidox inhibits the growth of human promyelocytic leukemia HL-60 cells with an IC50 of 35 μM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[References]

[1]. T Szekeres, et al. Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells. Blood. 1994 Dec 15;84(12):4316-21.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
480.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₇H₈N₂O₄

[ Molecular Weight ]:
184.15

[ Flash Point ]:
244.5±31.5 °C

[ Exact Mass ]:
184.048401

[ PSA ]:
116.80000

[ LogP ]:
-0.12

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.681

Related Compounds

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