CFTR corrector 12

Names

[ CAS No. ]:
958941-60-1

[ Name ]:
CFTR corrector 12

Biological Activity

[Description]:

CFTR corrector 12 (compound 17C) is a bithiazole derivative, serving as CFTR corrector. CFTR corrector 12 has the ability to correct some folding defective mutants of the channel responsible for the control of chloride transport across the plasma membrane. CFTR corrector 12 recovers the α-sarcoglycan (α-SG) content in mutant cells[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR
Research Areas >> Others

[References]

[1]. Ribaudo G, et al. Synthesis and Evaluation of Bithiazole Derivatives As Potential α-Sarcoglycan Correctors. ACS Med Chem Lett. 2023 Jul 28;14(8):1049-1053.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H21ClN4O2S2

[ Molecular Weight ]:
436.98

Related Compounds

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