N-[(4-Aminophenyl)methyl]adenosine

Names

[ Name ]:
N-[(4-Aminophenyl)methyl]adenosine

[Synonym ]:
1,2-Propanediol,3-((2-hydroxyethyl)nitrosoamino)
N-Nitroso-2,3-dihydroxypropyl-2-hydroxyethylamine
3-[(2-hydroxyethyl)(nitroso)amino]propane-1,2-diol
N-Nitrosodihydroxypropylethanolamine
N-Nitroso-2,3-dihydroxypropylethanolamine
N6-(p-aminobenzyl)-adenosine
Ndpea
3-((2-Hydroxyethyl)nitrosamino)-1,2-propanediol
1,2-Propanediol,3-((2-hydroxyethyl)nitrosamino)
N6-(4-amino-benzyl)-adenosine
[125I]-N6-(4-Aminobenzyl)adenosine
N-[(4-Aminophenyl)methyl]adenosine

Biological Activity

[Description]:

N-[(4-Aminophenyl)methyl]adenosine is a adenosine receptor inhibitor, with Ki of 29 nM for Rat ecto-5′-Nucleotidase.IC50 value: 29.0 ± 1.7 nM (Ki) Target: Adenosine Receptor

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

Research Areas >> Neurological Disease

[References]

[1]. Bhattarai S, et al. α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5'-Nucleotidase (CD73) Inhibitors. J Med Chem. 2015 Aug 13;58(15):6248-63.

[2]. Chen JB, et al. Design and synthesis of novel dual-action compounds targeting the adenosine A(2A) receptor and adenosine transporter for neuroprotection. ChemMedChem. 2011 Aug 1;6(8):1390-400.

[3]. Zhu Z, et al. Constrained NBMPR analogue synthesis, pharmacophore mapping and 3D-QSAR modeling of equilibrative nucleoside transporter 1 (ENT1) inhibitory activity. Bioorg Med Chem. 2008 Apr 1;16(7):3848-65.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.71g/cm3

[ Boiling Point ]:
749ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₂₀N₆O₄

[ Molecular Weight ]:
372.38

[ Flash Point ]:
406.8ºC

[ PSA ]:
93.36000

[ Index of Refraction ]:
1.8

Synthetic Route

Click to get detail synthetic route

Related Compounds

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