D-JBD19

Names

[ CAS No. ]:
954134-42-0

[ Name ]:
D-JBD19

Biological Activity

[Description]:

D-JBD19 is a non-permeable peptide[1]. D-JBD19 has neuroprotective effects[2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

D-JBD19 is a non-permeable cargo corresponding to dJNKi peptide[1].

[In Vivo]

Neuroprotective effects of D-JBD19 against middle cerebral artery occlusion (MCAO) as compared with D-JNKI1. 15.7 ng of either D-JBD19 or D-JNKI1 or 1570 ng of D-JBD19 are injected i.c.v. just after the ischemia. Animals were killed 24 h later. 100 times more D-JBD19 is needed to provide protection than with D-JNKI1[2].

[References]

[1]. Cardozo AK, et al. Cell-permeable peptides induce dose- and length-dependent cytotoxic effects. Biochim Biophys Acta. 2007 Sep;1768(9):2222-34.

[2]. Vaslin A, et al. Excitotoxicity-induced endocytosis mediates neuroprotection by TAT-peptide-linked JNK inhibitor. J Neurochem. 2011 Dec;119(6):1243-52.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉₉H₁₆₄N₃₂O₂₈

[ Molecular Weight ]:
2250.56

Related Compounds

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