ABT-288

Names

[ Name ]:
ABT-288

[Synonym ]:
ABT-288
2-{4'-[(3aR,6aR)-5-Methylhexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl]-4-biphenylyl}-3(2H)-pyridazinone
3(2H)-Pyridazinone, 2-[4'-[(3aR,6aR)-hexahydro-5-methylpyrrolo[3,4-b]pyrrol-1(2H)-yl][1,1'-biphenyl]-4-yl]-
5MEI1M3NHH

Biological Activity

[Description]:

ABT-288 is a potent, selective and competitive antagonist of H3 receptor with Ki of 1.9/8.2 nM for human/rat H3 respectively; enhances the release of acetylcholine and dopamine in rat prefrontal cortex; possesses excellent pharmacokinetics and oral bioavailability.

[References]

References 1. Esbenshade TA, et al. J Pharmacol Exp Ther. 2012 Oct;343(1):233-45. 2. Hudzik TJ, et al. Psychopharmacology (Berl). 2013 Jul;228(2):187-97. 3. Othman AA, et al. Br J Clin Pharmacol. 2014 Jun;77(6):965-74. View Related Products by Target Histamine Receptor

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
567.4±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₄N₄O

[ Molecular Weight ]:
372.463

[ Flash Point ]:
296.9±32.9 °C

[ Exact Mass ]:
372.195007

[ LogP ]:
2.72

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.683

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.