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ABT 089 2HCl

Names

[ CAS No. ]:
161416-61-1

[ Name ]:
ABT 089 2HCl

[Synonym ]:
2-Methyl-3-[(2S)-2-pyrrolidinylmethoxy]pyridine dihydrochloride
MFCD00929191
Pyridine, 2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]-, hydrochloride (1:2)
2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride
POZANICLINE DIHYDROCHLORIDE
ABT-089 dihydrochloride

Biological Activity

[Description]:

A potent and selective α4β2 nAChR agonist with Ki of 16 nM; display selectivity over α7 nAChR (Ki>10 uM) and α1β1 nAChR; displays a similar potency and efficacy to (-)-nicotine to facilitate ACh release (EC50=3 uM), with less potent and less efficacious stimulate dopamine release (ABT-089, EC50=1.1 uM; (-)-nicotine, EC50=0.04 uM); shows effects on cognitive performance in rats and monkeys. Alzheimer Disease Phase 2 Discontinued

[References]

References 1. Lin NH, et al. J Med Chem. 1997 Jan 31;40(3):385-90. 2. Sullivan JP, et al. J Pharmacol Exp Ther. 1997 Oct;283(1):235-46. 3. Decker MW, et al. J Pharmacol Exp Ther. 1997 Oct;283(1):247-58. View Related Products by Target nAChR Alzheimer Disease

Chemical & Physical Properties

[ Molecular Formula ]:
C11H16N2O.2HCl

[ Molecular Weight ]:
265.179

[ Exact Mass ]:
264.079620

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ RIDADR ]:
NONH for all modes of transport

Related Compounds