Aumitin

Names

[ Name ]:
Aumitin

Biological Activity

[Description]:

Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Neurological Disease

[References]

[1]. Robke L, et al. Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I. Chem Sci. 2018 Feb 26;9(11):3014-3022.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₀ClN₅O

[ Molecular Weight ]:
429.90

Related Compounds

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