946293-78-3

946293-78-3 structure

Name: Aumitin
Chemical Name: Aumitin
CAS Number: 946293-78-3
Molecular Formula: C₂₄H₂₀ClN₅O
Molecular Weight: 429.90
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2019-10-08 10:58:52
Modify Date: 2025-09-10 19:28:19
Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively[1].

Name	Aumitin

Description	Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Neurological Disease
References	[1]. Robke L, et al. Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I. Chem Sci. 2018 Feb 26;9(11):3014-3022.

Molecular Formula	C₂₄H₂₀ClN₅O
Molecular Weight	429.90