MJ 15

Names

[ Name ]:
MJ 15

[Synonym ]:
N-(3-aminomethyl-pyridin-2-yl)-N-methyl-methanesulphonamide
N-(3-(aminomethyl)pyridin-2-yl)-N-methylmethanesulfonamide
N-(3-aminomethylpyridyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl pyrazol-3-carboxamide

Biological Activity

[Description]:

MJ15 is a potent and selective CB1 receptor antagonist with a Ki of 27.2 pM and an IC50 of 118.9 pM for rat CB1 receptors. MJ15 exhibits potency in obesity and hyperlipidemia models. MJ15 inhibits food intake and increases in body weight in diet-induced obese rats and mice[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor

[Target]

rCB1-R:27.2 pM (Ki)

rCB1-R:118.9 pM (IC50)

[References]

[1]. Chen W, et al. Novel selective antagonist of the cannabinoid CB1 receptor, MJ15, with prominent anti-obesity effect in rodent models. Eur J Pharmacol. 2010 Jul 10;637(1-3):178-85.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₁₇Cl₃N₄O

[ Molecular Weight ]:
471.76600

[ Exact Mass ]:
470.04700

[ PSA ]:
63.30000

[ LogP ]:
6.70770

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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