944154-76-1
944154-76-1 structure
- Name: MJ 15
- Chemical Name: 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(3-pyridinyl methyl)-1H-pyrazole-3-carboxamide
- CAS Number: 944154-76-1
- Molecular Formula: C23H17Cl3N4O
- Molecular Weight: 471.76600
- Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
- Create Date: 2018-10-19 17:58:14
- Modify Date: 2024-01-07 11:13:41
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MJ15 is a potent and selective CB1 receptor antagonist with a Ki of 27.2 pM and an IC50 of 118.9 pM for rat CB1 receptors. MJ15 exhibits potency in obesity and hyperlipidemia models. MJ15 inhibits food intake and increases in body weight in diet-induced obese rats and mice[1].
| Name | 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(3-pyridinyl methyl)-1H-pyrazole-3-carboxamide |
|---|---|
| Synonyms |
N-(3-aminomethyl-pyridin-2-yl)-N-methyl-methanesulphonamide
N-(3-(aminomethyl)pyridin-2-yl)-N-methylmethanesulfonamide N-(3-aminomethylpyridyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl pyrazol-3-carboxamide |
| Description | MJ15 is a potent and selective CB1 receptor antagonist with a Ki of 27.2 pM and an IC50 of 118.9 pM for rat CB1 receptors. MJ15 exhibits potency in obesity and hyperlipidemia models. MJ15 inhibits food intake and increases in body weight in diet-induced obese rats and mice[1]. |
|---|---|
| Related Catalog | |
| Target |
rCB1-R:27.2 pM (Ki) rCB1-R:118.9 pM (IC50) |
| References |
| Molecular Formula | C23H17Cl3N4O |
|---|---|
| Molecular Weight | 471.76600 |
| Exact Mass | 470.04700 |
| PSA | 63.30000 |
| LogP | 6.70770 |
|
~%
944154-76-1 |
| Literature: Beijing Molecule Science and Technology Co., Ltd. Patent: EP1975168 A1, 2008 ; Location in patent: Page/Page column 3; 5; 7; 8 ; EP 1975168 A1 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |