Isorosmanol

Names

[ Name ]:
Isorosmanol

[Synonym ]:
2H-9,4a-(Epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6,10-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-, [4aR-(4aα,9α,10β,10aβ)]-
Isorosmanol
ISOROSMANOL

Biological Activity

[Description]:

Isorosmanol is an abietane-type diterpene isolated from the leaves of sage, with antioxidant, neuroprotective and neurotrophic effects. Isorosmanol inhibits AChE activity and melanin synthesis[1][2][3].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

[References]

[1]. Miura K, et al. Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method. J Agric Food Chem. 2002 Mar 27;50(7):1845-51.

[2]. Park SY, et al. Neuroprotective and neurotrophic effects of isorosmanol. Z Naturforsch C. 2009 May-Jun;64(5-6):395-8.

[3]. Sallam A, et al. Acetylcholine esterase inhibitors and melanin synthesis inhibitors from Salvia officinalis. Phytomedicine. 2016 Sep 15;23(10):1005-11.

Chemical & Physical Properties

[ Density]:
1.33±0.1 g/cm3 (20 °C, 760 mmHg)

[ Boiling Point ]:
569.5±50.0 °C (760 mmHg)

[ Molecular Formula ]:
C₂₀H₂₆O₅

[ Molecular Weight ]:
346.41700

[ Exact Mass ]:
346.17800

[ PSA ]:
86.99000

[ LogP ]:
3.25770

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H410

[ Precautionary Statements ]:
P273-P501

[ RIDADR ]:
UN 3077 9 / PGIII

Related Compounds

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