Salicylhydrazide

Names

[ CAS No. ]:
936-02-7

[ Name ]:
Salicylhydrazide

[Synonym ]:
MFCD00007599
2-hydroxybenzohydrazide
EINECS 213-311-3

Chemical & Physical Properties

[ Density]:
1.318g/cm3

[ Melting Point ]:
147-150 °C(lit.)

[ Molecular Formula ]:
C₇H₈N₂O₂

[ Molecular Weight ]:
152.15100

[ Exact Mass ]:
152.05900

[ PSA ]:
75.35000

[ LogP ]:
1.08690

[ Index of Refraction ]:
1.622

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VO3700000

CHEMICAL NAME :: Salicylic acid, hydrazide

CAS REGISTRY NUMBER :: 936-02-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H8-N2-O2

MOLECULAR WEIGHT :: 152.17

WISWESSER LINE NOTATION :: ZMVR BQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - monoamine oxidase

REFERENCE :: JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 4,259,1961

Safety Information

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ WGK Germany ]:
3

[ RTECS ]:
VO3700000

[ HS Code ]:
2928000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

Synthesis, Characterization, and Anticancer Activity of New Metal Complexes Derived from 2-Hydroxy-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide.

Bioinorg. Chem. Appl. 2015 , 126023, (2015)

Novel metal(II) complexes derived from 2-hydroxy-N'-((Z)-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide ligand (H2L) were synthesized and characterized by elemental and thermal analyses (DTA an...

Salicylidene salicylhydrazide, a selective inhibitor of beta 1-containing GABAA receptors.

Br. J. Pharmacol. 142 , 97-106 , (2004)

1. A high-throughput assay utilizing the voltage/ion probe reader (VIPR) technology identified salicylidene salicylhydrazide (SCS) as being a potent selective inhibitor of alpha2beta1gamma1 GABA(A) re...

Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors.

Bioorg. Med. Chem. Lett. 17(23) , 6472-5, (2007)

The previously discovered salicylhydrazide class of compounds displayed potent HIV-1 integrase (IN) inhibitory activity. The development of this class of compounds as antiretroviral agents was halted ...