Salicylhydrazide
Names
[ CAS No. ]:
936-02-7
[ Name ]:
Salicylhydrazide
[Synonym ]:
MFCD00007599
2-hydroxybenzohydrazide
EINECS 213-311-3
Chemical & Physical Properties
[ Density]:
1.318g/cm3
[ Melting Point ]:
147-150 °C(lit.)
[ Molecular Formula ]:
C7H8N2O2
[ Molecular Weight ]:
152.15100
[ Exact Mass ]:
152.05900
[ PSA ]:
75.35000
[ LogP ]:
1.08690
[ Index of Refraction ]:
1.622
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VO3700000
- CHEMICAL NAME :
- Salicylic acid, hydrazide
- CAS REGISTRY NUMBER :
- 936-02-7
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C7-H8-N2-O2
- MOLECULAR WEIGHT :
- 152.17
- WISWESSER LINE NOTATION :
- ZMVR BQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - monoamine oxidase
- REFERENCE :
- JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 4,259,1961
Safety Information
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ WGK Germany ]:
3
[ RTECS ]:
VO3700000
[ HS Code ]:
2928000090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2928000090
[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%
Articles
Bioinorg. Chem. Appl. 2015 , 126023, (2015)
Novel metal(II) complexes derived from 2-hydroxy-N'-((Z)-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide ligand (H2L) were synthesized and characterized by elemental and thermal analyses (DTA an...
Salicylidene salicylhydrazide, a selective inhibitor of beta 1-containing GABAA receptors.Br. J. Pharmacol. 142 , 97-106 , (2004)
1. A high-throughput assay utilizing the voltage/ion probe reader (VIPR) technology identified salicylidene salicylhydrazide (SCS) as being a potent selective inhibitor of alpha2beta1gamma1 GABA(A) re...
Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors.Bioorg. Med. Chem. Lett. 17(23) , 6472-5, (2007)
The previously discovered salicylhydrazide class of compounds displayed potent HIV-1 integrase (IN) inhibitory activity. The development of this class of compounds as antiretroviral agents was halted ...