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DAM-IN-1

Names

[ CAS No. ]:
935279-95-1

[ Name ]:
DAM-IN-1

[Synonym ]:
4-(Ethoxycarbonyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-carboxylic acid
3H-Cyclopenta[c]quinoline-4,8-dicarboxylic acid, 3a,4,5,9b-tetrahydro-, 4-ethyl ester

Biological Activity

[Description]:

DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor, IC50: 48 μM. DMA-IN-1 inhibits Caulobacter growth with an MIC of 35 μM[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[Target]

IC50: 48 μM (DNA adenine methyltransferase, DAM)[1]


[References]

[1]. Mashhoon N, et al. Selective inhibitors of bacterial DNA adenine methyltransferases. J Biomol Screen. 2006 Aug;11(5):497-510.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
447.3±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H17NO4

[ Molecular Weight ]:
287.310

[ Flash Point ]:
224.3±28.7 °C

[ Exact Mass ]:
287.115753

[ LogP ]:
2.85

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.584

Related Compounds

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