<Suppliers Price>

Iodoacetyl-LC-biotin

Names

[ CAS No. ]:
93285-75-7

[ Name ]:
Iodoacetyl-LC-biotin

[Synonym ]:
N-Iodoacetyl-N'-biotinyl-1,6-hexanediamine
N-IODOACETYL-N'-BIOTINYLHEXYLENEDIAMINE
iodoacetyl-LC-biotin

Biological Activity

[Description]:

Iodoacetyl-LC-biotin is a biotinylated electrophile probe that can be used to investigate the scope and characteristics of protein covalent binding to subcellular proteomes[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Others

[In Vitro]

Iodoacetyl-LC-biotin (IAB) (50-200 μM; 6-24 h) increases LDH leakage in HEK293 cells in a time- and dose-dependant manner[1]. IAB (50-200 µM; 24 h) causes the release of cytochrome c from the mitochondria to the cytosol in HEK293 cells[1].

[References]

[1]. Wong HL, et, al. Mitochondrial protein targets of thiol-reactive electrophiles. Chem Res Toxicol. 2008 Apr;21(4):796-804.

[2]. Davis KA, et, al. Staining of cell surface human CD4 with 2'-F-pyrimidine-containing RNA aptamers for flow cytometry. Nucleic Acids Res. 1998 Sep 1;26(17):3915-24.

Chemical & Physical Properties

[ Density]:
1.414g/cm3

[ Boiling Point ]:
793.7ºC at 760 mmHg

[ Molecular Formula ]:
C18H31IN4O3S

[ Molecular Weight ]:
510.43300

[ Flash Point ]:
433.8ºC

[ Exact Mass ]:
510.11600

[ PSA ]:
124.63000

[ LogP ]:
3.37940

[ Index of Refraction ]:
1.559

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds