Pexopiprant

Names

[ Name ]:
Pexopiprant

[Synonym ]:
{[8-Chloro-3-(4-chlorobenzyl)-4-(difluoromethoxy)-2-ethyl-5-quinolinyl]oxy}acetic acid
Acetic acid, 2-[[8-chloro-3-[(4-chlorophenyl)methyl]-4-(difluoromethoxy)-2-ethyl-5-quinolinyl]oxy]-

Biological Activity

[Description]:

Pexopiprant is an oral antagonist of the prostaglandin D2 receptor 2 (DP2),Ki ＜ 100nM. Pexopiprant can be used in studies of asthma[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

[Target]

hDP2:<100 nM (Ki)

[References]

[1]. Cramp, Michael Colin; Arienzo, Rosa; Hynd, George; Crackett, Peter; Griffon, Yann; Harrison, Trevor Keith; Ray, Nicholas Charles; Finch, Harry; Montana, John Gary.Preparation of quinoline derivatives as CRTH2 antagonists. WO2007036743 A2.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
539.5±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₁₇Cl₂F₂NO₄

[ Molecular Weight ]:
456.27

[ Flash Point ]:
280.1±28.7 °C

[ Exact Mass ]:
455.050262

[ LogP ]:
6.04

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.601

Related Compounds

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