DL-γ-Amino-β-hydroxybutyric acid

Names

[ CAS No. ]:
924-49-2

[ Name ]:
DL-γ-Amino-β-hydroxybutyric acid

[Synonym ]:
3-Hydroxy-4-aminobutyric acid
γ-amino-β-hydroxybutyric acid
3-hydroxy-4-amino-butyric acid (GABOB)
3-hydroxy-GABA
β-Hydroxy-GABA
3-hydroxy-4-amino-butyric acid
Butanoic acid, 4-amino-3-hydroxy-
β-Hydroxy-γ-aminobutyric acid
4-Amino-3-hydroxybutanoic acid
g-Amino-b-hydroxybutyric Acid
EINECS 213-106-9
DL-4-Amino-3-hydroxybutanoic acid
DL-γ-AMINO-B-HYDROXYBUTYRIC ACIDCRYS TALLINE
DL-4-Amino-3-hydroxybutyric acid
MFCD00008141
(±)-4-Amino-3-hydroxybutyric acid
γ-Amino-β-hydroxy-n-butyric acid
UNII:1ZHM019FLD
z-gabob-oh

Biological Activity

[Description]:

Gamibetal is the gamma-amino-beta-hydroxybutyric acid. Gamibetal has the potential for the research of epilepsy[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[Target]

Human Endogenous Metabolite

[References]

[1]. Grbesa B, et al. Gamibetal (gama-amino-beta-hidroksibuterna kiselina--GABOB) u lecenju epilepsije [Gamibetal (gamma-amino-beta-hydroxybutyric acid--GABOB) in the treatment of epilepsy]. Med Glas. 1967;21(3):75-77.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
374.5±32.0 °C at 760 mmHg

[ Melting Point ]:
223ºC (dec.)(lit.)

[ Molecular Formula ]:
C₄H₉NO₃

[ Molecular Weight ]:
119.119

[ Flash Point ]:
180.3±25.1 °C

[ Exact Mass ]:
119.058243

[ PSA ]:
83.55000

[ LogP ]:
-1.73

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.511

[ Water Solubility ]:
almost transparency

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
ES7015000

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors.

Bioorg. Med. Chem. Lett. 18 , 402-4, (2008)

The R- and S-enantiomers of 4-amino-3-hydroxybutanoic acid (GABOB) were full agonists at human recombinant rho1 GABA(C) receptors. Their enantioselectivity (R>S) matched that reported for their agonis...

GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol.

J. Med. Chem. 28(11) , 1612-7, (1985)

(RS)-5-(Aminomethyl)-2-isoxazolin-3-ol (dihydromuscimol, DHM) is a potent 4-aminobutyric acid (GABA) agonist, the inhibitory effects of which on neurons are sensitive to the antagonist bicuculline met...

Formation of gamma-amino-beta-hydroxybutyric acid from 2-hydroxyputrescine in rat brain.

J. Neurochem. 51(2) , 548-51, (1988)

gamma-Amino-beta-[3H]hydroxybutyric acid ([3H]-GABOB) was formed in rat brain from 2-[3H]-hydroxyputrescine that had been chemically synthesized from 2-oxoputrescine and [3H]sodium borohydride. After ...