2,3-Naphthalenediol
Names
[ CAS No. ]:
92-44-4
[ Name ]:
2,3-Naphthalenediol
[Synonym ]:
2,3-Dihydroxy naphthalene
2,3-DIHYDROXY-NAPHTHALENE
naphthalene-2,3-diol
2,3-Naphthalenediol
MFCD00004073
EINECS 202-156-7
2,3-dihydroxynaphthalene
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
353.9±15.0 °C at 760 mmHg
[ Melting Point ]:
161-165 °C(lit.)
[ Molecular Formula ]:
C10H8O2
[ Molecular Weight ]:
160.17
[ Flash Point ]:
181.0±15.0 °C
[ Exact Mass ]:
160.052429
[ PSA ]:
40.46000
[ LogP ]:
2.11
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.726
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
slightly soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QJ4750000
- CHEMICAL NAME :
- 2,3-Naphthalenediol
- CAS REGISTRY NUMBER :
- 92-44-4
- BEILSTEIN REFERENCE NO. :
- 0742375
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C10-H8-O2
- MOLECULAR WEIGHT :
- 160.18
- WISWESSER LINE NOTATION :
- L66J CQ DQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03884 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83337 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 30 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83337 No. of Facilities: 644 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 5646 (estimated) No. of Female Employees: 2925 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S37/39
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
QJ4750000
[ HS Code ]:
2907299090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2907299090
[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%
Articles
Drug Metab. Dispos. 43(1) , 126-39, (2014)
Although skin is the largest organ of the human body, cutaneous drug metabolism is often overlooked, and existing experimental models are insufficiently validated. This proof-of-concept study investig...
The syntheses and characterizations of molybdenum(VI) complexes with catechol and 2,3-dihydroxynaphthalene, and the structure-effect relationship in their in vitro anticancer activities.Dalton Trans. 41(28) , 8697-702, (2012)
The reactions of (NH(4))(2)Mo(2)O(7)·2H(2)O with polyhydroxy phenols (catechol or 2,3-dihydroxynaphthalene) and ethylenediamine (en), trimethylenediamine (tn), 1,2-propanediamine (pn), triethylamine (...
Selective antiproliferative activity of hydroxynaphthyl-beta-D-xylosides.J. Med. Chem. 49 , 1932-8, (2006)
The antiproliferative activity of the 14 isomeric monoxylosylated dihydroxynaphthalenes has been tested in vitro toward normal HFL-1 and 3T3 A31 cells as well as transformed T24 and 3T3 SV40 cells. Th...