Timolol hemihydrate

Names

[ CAS No. ]:
91524-16-2

[ Name ]:
Timolol hemihydrate

[Synonym ]:
timolol.0.5H2O
Timolol hemihydrate
(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol,hydrate
UNII-817W3C6175

Biological Activity

[Description]:

Timolol (hemihydrate) is a β-blocker available for both topical and systemic administration. Timolol (hemihydrate) is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension and Timolol (hemihydrate) also has cardioprotective effect[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[In Vitro]

Timolol (hemihydrate) can significantly prevent the increased lipid peroxidation level of the heart from diabetic rats. Timolol (hemihydrate) can induce a well-balanced ratio between oxidative stress and antioxidant defense system in the diabetic animals, can have an important cardioprotection against diabetes-induced ERS and associated apoptotic effects[3].

[In Vivo]

Timolol (hemihydrate) (5 mg/kg daily for 12-week) has a cardioprotective effect via inhibition of ERS response in diabetic rats[3]. Animal Model: Male Wistar rats[3]. Dosage: 5 mg/kg Administration: Timolol (5 mg/kg daily for 12-week) Result: Showed cardioprotective effect.

[References]

[1]. Figen Amber Cicek, et al. Beta-blocker timolol alleviates hyperglycemia-induced cardiac damage via inhibition of endoplasmic reticulum stress. J Bioenerg Biomembr

[2]. E. Ansari, et al. Treatment of open-angle glaucoma and ocular hypertension with preservative-free tafuprost/timolol fxed-dose combination therapy: 6 case reports and clinical outcomes. BMC Ophthalmol. 2022 Apr 2;22(1):152.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H50N8O7S2

[ Molecular Weight ]:
650.85500

[ Exact Mass ]:
650.32400

[ PSA ]:
225.19000

[ LogP ]:
1.85250

Related Compounds