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Methotrexate

Names

[ CAS No. ]:
91431-42-4

[ Name ]:
Methotrexate

[Synonym ]:
6-chloro-1,4-diacetoxy-2,3-dimethoxynaphthalene
LONAPALENE
Lonapaleno
Lonapalenum
6-chloro-2,3-dimethoxy-1,4-naphthalenediol
1,4-diacetoxy-6-chloro-2,3-dimethoxynaphthalene
6-chloro-1,4-diacetyloxy-2,3-dimethoxynaphthalene
Methotrexate
RS4317

Biological Activity

[Description]:

RS4317 is a topically effective 5-lipoxygenase (5-LO) inhibitor.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
Research Areas >> Inflammation/Immunology

[Target]

5-lipoxygenase[1]


[In Vitro]

RS4317 (Lonapalene) may be useful in the treatment of psoriasis, and that leukotriene B4 is a relevant mediator of the pathology of this disease[1].

[References]

[1]. Black AK, et al. Pharmacologic and clinical effects of lonapalene (RS 43179), a 5-lipoxygenase inhibitor, in psoriasis. J Invest Dermatol. 1990 Jul;95(1):50-4.


[Related Small Molecules]

U73122 | Zileuton | ML355 | Nordihydroguaiaretic acid | Indirubin-3'-monoxime | Caffeic acid | marmesin | Malotilate | 4',5-Dihydroxyflavone | Enazadrem | LY 178002 | RWJ 63556 | S-2474 | 5-Lipoxygenase-In-1 | A-69412

Chemical & Physical Properties

[ Density]:
1.309g/cm3

[ Boiling Point ]:
424.9ºC at 760mmHg

[ Molecular Formula ]:
C16H15ClO6

[ Molecular Weight ]:
338.74000

[ Flash Point ]:
159.3ºC

[ Exact Mass ]:
338.05600

[ PSA ]:
71.06000

[ LogP ]:
3.36100

[ Index of Refraction ]:
1.571

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds