Difluoxacin hydrochloride

Names

[ Name ]:
Difluoxacin hydrochloride

[Synonym ]:
MFCD03840489
6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid,hydrochloride

Biological Activity

[Description]:

Difloxacin hydrochloride is a broad-spectrum antibacterial drug. Difloxacin hydrochloride inhibits bacterial DNA gyrase and exhibits a concentration-dependant bactericidal effect by interference with the activity of DNA gyrase and topoisomerase IV[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Abo El-Ela FI, et al. Pharmacokinetics of difloxacin in healthy and E. coli-infected broiler chickens. Br Poult Sci. 2014;55(6):830-6.

Chemical & Physical Properties

[ Density]:
1.409 g/cm3

[ Boiling Point ]:
595.5ºC at 760 mmHg

[ Melting Point ]:
>245ºC (dec.)

[ Molecular Formula ]:
C₂₁H₂₀ClF₂N₃O₃

[ Molecular Weight ]:
435.852

[ Flash Point ]:
313.9ºC

[ Exact Mass ]:
435.116119

[ PSA ]:
65.78000

[ LogP ]:
3.52380

[ Index of Refraction ]:
1.629

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
T+

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
VB2008975

Articles

Determination of fluoroquinolones in chicken feces - a new liquid-liquid extraction method combined with LC-MS/MS.

Environ. Toxicol. Pharmacol. 38(3) , 792-9, (2014)

The application of antibiotics including fluoroquinolones to farming animals is widespread and may lead to the development of antibiotic resistance and other environmental effects. To calculate enviro...

Occurrence and distribution of antibiotics in urban soil in Beijing and Shanghai, China.

Environ. Sci. Pollut. Res. Int. 22 , 11360-71, (2015)

The recycling of reclaimed wastewater for irrigation and road cleaning is an important strategy to minimize water scarcity in megacities. However, little is known regarding the potential accumulation ...

Facile synthesis of polyaniline-coated SiO₂ nanofiber and its application in enrichment of fluoroquinolones from honey samples.

Talanta 140 , 29-35, (2015)

In this study, polyaniline coated SiO2 nanofibers (PANI/SiO2) was prepared by combining electrospinning technique with in-situ polymerization. The proposed strategy for the preparation of PANI/SiO2 ca...