ML-261

Names

[ Name ]:
ML-261

[Synonym ]:
2-Chloro-N-[2-(3,4-diethoxyphenyl)ethyl]-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxamide
4H-Thieno[3,2-b]pyrrole-5-carboxamide, 2-chloro-N-[2-(3,4-diethoxyphenyl)ethyl]-4-methyl-

Biological Activity

[Description]:

ML261 is a hepatic lipid droplets formation inhibitor with an IC50 value of 69.7 nM. ML261 can be used for the research of non-alcoholic fatty liver disease (NAFLD) and inflammation[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

IC50: 69.7 nM (hepatic lipid droplets formation)[1]

[In Vitro]

ML261 (1 nM-10 μM; 24 h) affects hepatic lipid droplets formation in murine AML-12 cells[1]. Cell Viability Assay[1] Cell Line: AML-12 cells Concentration: 1 nM-10 μM Incubation Time: 24 hours Result: Inhibited hepatic lipid droplets formation with an IC50 value of 69.7 nM.

[References]

[1]. Zou J, et al. Potent inhibitors of lipid droplet formation. 2014.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
625.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₃ClN₂O₃S

[ Molecular Weight ]:
406.926

[ Flash Point ]:
332.0±31.5 °C

[ Exact Mass ]:
406.111786

[ PSA ]:
84.22000

[ LogP ]:
5.45

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.610

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ RIDADR ]:
UN 2811 6.1 / PGIII