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Dimethicone

Names

[ CAS No. ]:
9006-65-9

[ Name ]:
Dimethicone

[Synonym ]:
Dimethicone

Biological Activity

[Description]:

Dimethicone is an orally active biochemical assay reagents consisting of a fully methylated linear siloxane polymer whose ends are blocked by trimethylsiloxane units. Dimethicone can lubricate hair and physically block the respiratory system of lice to remove lice. Dimethicone has potential applications in cosmetics and daily cleaning products[1][2][3].

[Related Catalog]:

Research Areas >> Others

[In Vivo]

Dimethicone (25% 溶于石油醚；呼吸道给药；单剂量) 在 Wistar 大鼠中显示出生物安全性[3]。 Dimethicone (饮食中含 1%、5% 或 10%；口服；90 d) 在 Sprague-Dawley 大鼠中显示出生物安全性[3]。

[References]

[1]. Nair B, et al. Final report on the safety assessment of stearoxy dimethicone, dimethicone, methicone, amino bispropyl dimethicone, aminopropyl dimethicone, amodimethicone, amodimethicone hydroxystearate, behenoxy dimethicone, C24-28 alkyl methicone, C30-45 alkyl methicone, C30-45 alkyl dimethicone, cetearyl methicone, cetyl dimethicone, dimethoxysilyl ethylenediaminopropyl dimethicone, hexyl methicone, hydroxypropyldimethicone, stearamidopropyl dimethicone, stearyl dimethicone, stearyl methicone, and vinyldimethicone. Int J Toxicol. 2003;22 Suppl 2:11-35.

[2]. Ihde ES, et al. Safety and efficacy of a 100% dimethicone pediculocide in school-age children. BMC Pediatr. 2015 Jun 20;15:70.  

[3]. Shank P D, et al. Safety Assessment of Dimethicone, Methicone, and Substituted-Methicone Polymers, as Used in Cosmetics[J]. 2020.

Chemical & Physical Properties

[ Density]:
1 g/mL at 20 °C

[ Molecular Formula ]:
C6H18OSi2

[ Molecular Weight ]:
162.37800

[ Flash Point ]:
121 °C

[ Exact Mass ]:
162.09000

[ PSA ]:
9.23000

[ LogP ]:
2.67280

[ Vapour Pressure ]:
5 mm Hg ( 20 °C)

[ Index of Refraction ]:
n20/D 1.406

[ Storage condition ]:
2~8°C

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents, reducing agents, organics, acids, alkalis. Corrodes many metals.

[ Water Solubility ]:
Practically insoluble in water, very slightly soluble or practically insoluble in anhydrous ethanol, miscible with ethyl acetate, with methyl ethyl ketone and with toluene.

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
24/25-26

[ WGK Germany ]:
3

[ RTECS ]:
TQ2690000

Related Compounds