MMP2-IN-3

Names

[ Name ]:
MMP2-IN-3

Biological Activity

[Description]:

MMP2-IN-3 (compound 2) is a potent MMP-2 (matrix metalloproteinases) inhibitor, with an IC50 of 31 μM. MMP2-IN-3 also shows inhibitory activity against MMP-9 and MMP-8, with IC50 values of 26.6, and 32 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[Target]

MMP-9:26.6 ± 2.3 μM (IC50)

MMP-2:31 ± 5 μM (IC50)

MMP-8:32 ± 4 μM (IC50)

MMP-13:>100 μM (IC50)

[References]

[1]. Laghezza A, et al. Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors. Bioorg Med Chem. 2020 Feb 1;28(3):115257.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₁N₃O

[ Molecular Weight ]:
355.43

Related Compounds

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