KX2-361

Names

[ Name ]:
KX2-361

[Synonym ]:
N-(3-Fluorobenzyl)-2-{5-[4-(4-morpholinyl)phenyl]-2-pyridinyl}acetamide
RVW387BA9U
2-Pyridineacetamide, N-[(3-fluorophenyl)methyl]-5-[4-(4-morpholinyl)phenyl]-

Biological Activity

[Description]:

KX2-361 (KX-02) is a Src-kinase and tubulin polymerization inhibitor. KX2-361 shows good oral bioavailability and readily crosses the BBB in mice. KX2-361 shows anti-tumor activity and induces apoptosis of Glioblastoma (GBM) cell[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[References]

[1]. Ciesielski MJ, et al. KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma. J Neurooncol. 2018 Dec;140(3):519-527.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
660.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₄FN₃O₂

[ Molecular Weight ]:
405.46

[ Flash Point ]:
353.0±31.5 °C

[ Exact Mass ]:
405.185242

[ LogP ]:
2.00

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.598

Related Compounds

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