2-[(4R)-4-Hydroxy-2-oxo-1-pyrrolidinyl]acetamide

Names

[ Name ]:
2-[(4R)-4-Hydroxy-2-oxo-1-pyrrolidinyl]acetamide

[Synonym ]:
1-PYRROLIDINEACETAMIDE,4-HYDROXY-2-OXO-, (4S)-
(S)-2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide
2-[(4S)-4-hydroxy-2-oxopyrrolidin-1-yl]acetamide
S-(-)-Oxiracetam
oxiracetam
1-Pyrrolidineacetamide, 4-hydroxy-2-oxo-, (S)-
(S)-Oxiracetam
2-[(4R)-4-Hydroxy-2-oxo-1-pyrrolidinyl]acetamide
(S)-4-Hydroxy-2-oxo-1-pyrrolidineacetamide
1-Pyrrolidineacetamide, 4-hydroxy-2-oxo-, (4R)-

Biological Activity

[Description]:

(S)-oxiracetam (S-ORC) is an inhibitor targeting apoptosis. S-ORC reduces brain infarct size and lessens neurological dysfunction in middle cerebral artery occlusion/reperfusion (MCAO/R) models. S-ORC prevents neuronal apoptosis via activating PI3K/Akt/GSK3β signaling pathway via α7 nAChR after ischemic stroke. S-ORC can prevent neuronal death after ischemic stroke[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Neurological Disease

[References]

[1]. Fan W, et al. S-oxiracetam ameliorates ischemic stroke induced neuronal apoptosis through up-regulating α7 nAChR and PI3K / Akt / GSK3β signal pathway in rats. Neurochem Int. 2018 May;115:50-60.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
494.6±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆H₁₀N₂O₃

[ Molecular Weight ]:
158.16

[ Flash Point ]:
252.9±27.3 °C

[ Exact Mass ]:
158.069138

[ PSA ]:
83.63000

[ LogP ]:
-2.48

[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C

[ Index of Refraction ]:
1.570

Related Compounds

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