88929-35-5

88929-35-5 structure

Name: 2-[(4R)-4-Hydroxy-2-oxo-1-pyrrolidinyl]acetamide
Chemical Name: 1-Pyrrolidineacetamide, 4-hydroxy-2-oxo-, (4S)
CAS Number: 88929-35-5
Molecular Formula: C₆H₁₀N₂O₃
Molecular Weight: 158.16
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-02-23 08:00:00
Modify Date: 2024-01-02 22:12:00
(S)-oxiracetam (S-ORC) is an inhibitor targeting apoptosis. S-ORC reduces brain infarct size and lessens neurological dysfunction in middle cerebral artery occlusion/reperfusion (MCAO/R) models. S-ORC prevents neuronal apoptosis via activating PI3K/Akt/GSK3β signaling pathway via α7 nAChR after ischemic stroke. S-ORC can prevent neuronal death after ischemic stroke[1].

Name	1-Pyrrolidineacetamide, 4-hydroxy-2-oxo-, (4S)
Synonyms	1-PYRROLIDINEACETAMIDE,4-HYDROXY-2-OXO-, (4S)- (S)-2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide 2-[(4S)-4-hydroxy-2-oxopyrrolidin-1-yl]acetamide S-(-)-Oxiracetam oxiracetam 1-Pyrrolidineacetamide, 4-hydroxy-2-oxo-, (S)- (S)-Oxiracetam 2-[(4R)-4-Hydroxy-2-oxo-1-pyrrolidinyl]acetamide (S)-4-Hydroxy-2-oxo-1-pyrrolidineacetamide 1-Pyrrolidineacetamide, 4-hydroxy-2-oxo-, (4R)-

Description	(S)-oxiracetam (S-ORC) is an inhibitor targeting apoptosis. S-ORC reduces brain infarct size and lessens neurological dysfunction in middle cerebral artery occlusion/reperfusion (MCAO/R) models. S-ORC prevents neuronal apoptosis via activating PI3K/Akt/GSK3β signaling pathway via α7 nAChR after ischemic stroke. S-ORC can prevent neuronal death after ischemic stroke[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Neurological Disease
References	[1]. Fan W, et al. S-oxiracetam ameliorates ischemic stroke induced neuronal apoptosis through up-regulating α7 nAChR and PI3K / Akt / GSK3β signal pathway in rats. Neurochem Int. 2018 May;115:50-60.