Atrial Natriuretic Factor (1-28) (mouse, rabbit, rat) trifluoroacetate salt

Names

[ Name ]:
Atrial Natriuretic Factor (1-28) (mouse, rabbit, rat) trifluoroacetate salt

[Synonym ]:
ranf
ranp
cardionatrin
MFCD00076228
anp 1-28,rat
anf 1-28
SLRRSSCFGGRIDRIGAQSGLGCNSFRY(Disulfidebridge:7-23)
SER-LEU-ARG-ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-ILE-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR: SLRRSSCFGGRIDRIGAQSGLGCNSFRY DISULFIDE BRIDGE CYS7-CYS23
SER-SER-CYS-PHE-GLY-GLY-ARG-ILE-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG(DISULFIDE BRIDGE:CYS3-CYS18)
ANF (1-28),RAT
α-Atriopeptin
SER-LEU-ARG-ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-ILE-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR(DISULFIDE BRIDGE:CYS7-CYS23)
Atrial Natriuretic Peptide (ANP) (1-28), rat

Biological Activity

[Description]:

Atrial Natriuretic Peptide (ANP) (1-28), rat is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor

Peptides

Research Areas >> Cardiovascular Disease

[Target]

Endothelin-1[1]

[In Vitro]

Rat ANP (1-28) and rat BNP-45, which are the respective major circulating forms of ANP and BNP in rats, potently inhibited Ang II-stimulated endothelin-1 secretion in a concentration-dependent manner. Rat ANP (5-25) is less effective that Rat ANP(1-28) with respect to inhibiting immunoreactive (ir)-endothelin-1 secretion and increasing cellular cyclic GMP. Rat ANP (1-28) inhibits the secretion of ir-endothelin-1 in a concentration-dependent manner between 0.01 and 1 μM[1].

[References]

[1]. Kohno M, et al. Angiotensin II stimulates endothelin-1 secretion in cultured rat mesangial cells. Kidney Int. 1992 Oct;42(4):860-6.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂₈H₂₀₅N₄₅O₃₉S₂

[ Molecular Weight ]:
3062.41000

[ Exact Mass ]:
3060.49000

[ PSA ]:
1453.98000

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

Articles

Atrial natriuretic peptide increases inflammation, infarct size, and mortality after experimental coronary occlusion.

Am. J. Physiol. Heart Circ. Physiol. 296 , H655-61, (2009)

Acute coronary artery occlusion triggers the release of atrial natriuretic peptide (ANP) from the heart. ANP affects vasodilation, natriuresis, and inflammation, but the integrated biological effects ...