88898-17-3

88898-17-3 structure

Name: Atrial Natriuretic Factor (1-28) (mouse, rabbit, rat) trifluoroacetate salt
Chemical Name: Atrial natriuretic factor (1-28) (rat)
CAS Number: 88898-17-3
Molecular Formula: C₁₂₈H₂₀₅N₄₅O₃₉S₂
Molecular Weight: 3062.41000
Catalog: Peptides
Create Date: 2018-06-19 17:45:05
Modify Date: 2024-01-02 20:39:08
Atrial Natriuretic Peptide (ANP) (1-28), rat is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.

Name	Atrial natriuretic factor (1-28) (rat)
Synonyms	ranf ranp cardionatrin MFCD00076228 anp 1-28,rat anf 1-28 SLRRSSCFGGRIDRIGAQSGLGCNSFRY(Disulfidebridge:7-23) SER-LEU-ARG-ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-ILE-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR: SLRRSSCFGGRIDRIGAQSGLGCNSFRY DISULFIDE BRIDGE CYS7-CYS23 SER-SER-CYS-PHE-GLY-GLY-ARG-ILE-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG(DISULFIDE BRIDGE:CYS3-CYS18) ANF (1-28),RAT α-Atriopeptin SER-LEU-ARG-ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-ILE-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR(DISULFIDE BRIDGE:CYS7-CYS23) Atrial Natriuretic Peptide (ANP) (1-28), rat

Description	Atrial Natriuretic Peptide (ANP) (1-28), rat is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor Peptides Research Areas >> Cardiovascular Disease
Target	Endothelin-1[1]
In Vitro	Rat ANP (1-28) and rat BNP-45, which are the respective major circulating forms of ANP and BNP in rats, potently inhibited Ang II-stimulated endothelin-1 secretion in a concentration-dependent manner. Rat ANP (5-25) is less effective that Rat ANP(1-28) with respect to inhibiting immunoreactive (ir)-endothelin-1 secretion and increasing cellular cyclic GMP. Rat ANP (1-28) inhibits the secretion of ir-endothelin-1 in a concentration-dependent manner between 0.01 and 1 μM[1].
References	[1]. Kohno M, et al. Angiotensin II stimulates endothelin-1 secretion in cultured rat mesangial cells. Kidney Int. 1992 Oct;42(4):860-6.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport