c-FMS inhibitor

Names

[ Name ]:
c-FMS inhibitor

[Synonym ]:
4-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(4-methylpiperidin-1-yl)phenyl)-1H-pyrrole-2-carboxamide
c-FMS inhibitor
4-Cyano-N-[4-(4-methyl-1-piperazinyl)-2-(4-methyl-1-piperidinyl)phenyl]-1H-pyrrole-2-carboxamide
arylamide,8

Biological Activity

[Description]:

c-FMS inhibitor is a novel c-Fms kinase inhibitor with a potential as anti-inflammatory agent and antirheumatic agent.IC50 value:Target: c-Fms

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Fms

Research Areas >> Inflammation/Immunology

[References]

[1]. Meegalla, Sanath K.; Wall, Mark J.; Chen, Jinsheng et al. Structure-based optimization of a potent class of arylamide FMS inhibitors. Bioorganic & Medicinal Chemistry Letters (2008), 18(12), 3632-3637.

[2]. Illig, Carl R.; Chen, Jinsheng; Wall, Mark J. et al. Discovery of novel FMS kinase inhibitors as anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters (2008), 18(5), 1642-1648.

[Related Small Molecules]

Pexidartinib | BLZ945 | GW2580 | OSI-930 | Ki20227 | cFMS-IN-2 | PLX647

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₃₀N₆O

[ Molecular Weight ]:
406.52400

[ Exact Mass ]:
406.24800

[ PSA ]:
78.40000

[ LogP ]:
3.26768

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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