Suc-Ala-Ala-Pro-Phe-AMC

Names

[ CAS No. ]:
88467-45-2

[ Name ]:
Suc-Ala-Ala-Pro-Phe-AMC

[Synonym ]:
MFCD00080246
SUC-ALA-ALA-PRO-PHE-AMC
FACTOR XIIA SUBSTRATE DIHYDROCHLORIDE

Biological Activity

[Description]:

Suc-AAPF-AMC is an α-chymotrypsin fluorogenic substrate for the quantitative determination of chymotrypsin activity[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Urja S Lathia, et al. Development of inductively coupled plasma-mass spectrometry-based protease assays. Anal Biochem. 2010 Mar 1;398(1):93-8.

Chemical & Physical Properties

[ Density]:
1.347 g/cm3

[ Boiling Point ]:
1056.4ºC at 760 mmHg

[ Molecular Formula ]:
C₃₄H₃₉N₅O₉

[ Molecular Weight ]:
661.70200

[ Flash Point ]:
592.7ºC

[ Exact Mass ]:
661.27500

[ PSA ]:
204.22000

[ LogP ]:
2.81620

[ Index of Refraction ]:
1.613

[ Storage condition ]:
20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3.

Bioorg. Med. Chem. 23(5) , 1123-34, (2015)

Proteinase 3 (Pr3), and human neutrophil elastase (HNE) are two major neutrophilic serine proteases (NsPs) expressed in neutrophil azurophil granules. Emerging data suggest that excessive release of p...

Evidence of cell-associated proteinases from Virgibacillus sp. SK33 isolated from fish sauce fermentation.

J. Food Sci. 76(3) , C413-9, (2011)

Cell-associated proteinases from Virgibacillus sp. SK33 isolated from fish sauce fermentation were extracted and characterized. Proteinases were effectively released when washed cells were incubated i...

Ascidian sperm chymotrypsin-like enzyme; participation in fertilization.

Experientia 39 , 377, (1983)

The action of a chymotrypsin-like enzyme from sperm extract from the ascidian Halocynthia roretzi was studied using several substrates. It was found that the most susceptible substrate had the most po...