DSS30

Names

[ CAS No. ]:
883027-32-5

[ Name ]:
DSS30

Biological Activity

[Description]:

DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid (Aβ) secretion by inhibiting amyloid precursor protein lyase 1 (BACEl) phosphorylation. DSS30 can be used in the study of neurodegenerative diseases such as Alzheimer's disease[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[In Vitro]

DSS30 (50 μM, 2 hours) inhibits the activity of the P25/CDK5 complex by up to 50% and the phosphorylation of BACE1 or Tau[1]. Western Blot Analysis[1] Cell Line: Expressed P25 PC12tet-off cell lines Concentration: 50 μM Incubation Time: 8 hours Result: Inhibited BACE1 phosphorylation by 12%.

[References]

[1]. Sul-Hee Chung, et al. Pharmaceutical composition comprising a p25/cdk5 inhibitor for preventing or treating a neurodegenerative disease. WO2006075808

Chemical & Physical Properties

[ Molecular Formula ]:
C16H14ClNO3S2

[ Molecular Weight ]:
367.87