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SC-99

Names

[ CAS No. ]:
882290-02-0

[ Name ]:
SC-99

Biological Activity

[Description]:

A novel selective STAT3 inhibitor that inhibits JAK2-STAT3 activation but has no effects on other transcription factors such as NF-κB, and kinases such as AKT, ERK, and c-Src; inhibits STAT3 phosphorylation, dimerization and nuclear translocation, downregulates STAT3-modulated gene expression and induces MM cell apoptosis; delays tumor growth in MM xenograft models (30mg/kg); orally active.

[References]

References 1. Zhang Z, et al. Oncotarget. 2016 Feb 23;7(8):9296-308. 2. Xu Z, et al. Acta Pharmacol Sin. 2017 May;38(5):651-659. View Related Products by Target STAT

Chemical & Physical Properties

[ Density]:
1.38±0.1 g/cm3(Predicted)

[ Boiling Point ]:
459.4±55.0 °C(Predicted)

[ Molecular Formula ]:
C15H8Cl2FN3O

[ Molecular Weight ]:
336.147

Safety Information

[ Hazard Codes ]:
Xn


Related Compounds