882290-02-0
882290-02-0 structure
- Name: SC-99
- Chemical Name: SC-99
- CAS Number: 882290-02-0
- Molecular Formula: C15H8Cl2FN3O
- Molecular Weight: 336.147
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-01-11 17:42:42
- Modify Date: 2024-01-23 19:28:26
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A novel selective STAT3 inhibitor that inhibits JAK2-STAT3 activation but has no effects on other transcription factors such as NF-κB, and kinases such as AKT, ERK, and c-Src; inhibits STAT3 phosphorylation, dimerization and nuclear translocation, downregulates STAT3-modulated gene expression and induces MM cell apoptosis; delays tumor growth in MM xenograft models (30mg/kg); orally active.
| Name | SC-99 |
|---|
| Description | A novel selective STAT3 inhibitor that inhibits JAK2-STAT3 activation but has no effects on other transcription factors such as NF-κB, and kinases such as AKT, ERK, and c-Src; inhibits STAT3 phosphorylation, dimerization and nuclear translocation, downregulates STAT3-modulated gene expression and induces MM cell apoptosis; delays tumor growth in MM xenograft models (30mg/kg); orally active. |
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| References | References 1. Zhang Z, et al. Oncotarget. 2016 Feb 23;7(8):9296-308. 2. Xu Z, et al. Acta Pharmacol Sin. 2017 May;38(5):651-659. View Related Products by Target STAT |
| Density | 1.38±0.1 g/cm3(Predicted) |
|---|---|
| Boiling Point | 459.4±55.0 °C(Predicted) |
| Molecular Formula | C15H8Cl2FN3O |
| Molecular Weight | 336.147 |
| Hazard Codes | Xn |
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