SC 19220

Names

[ CAS No. ]:
19395-87-0

[ Name ]:
SC 19220

[Synonym ]:
Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide
Lopac-S-3065
N'-Acetyl-8-chlorodibenzo[b,f][1,4]oxazepine-10(11H)-carbohydrazide
Dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide
N,N-Dimethylsphingosine
Tocris-1206
8-Chlor-10,11-dihydro-dibenz<b,f><1,4>oxazepin-10-carbonsaeure-N'-acetyl-hydrazid

Biological Activity

[Description]:

SC-19220 is a competitive prostaglandinn E2 receptor antagonist. SC-19220 increases the bladder capacity and reduced the voiding efficiency of micturition (elicited by slow transvesical filling) of urethane-anesthetized rats. SC-19220 can restores the balance in bone marrow granulocyte and monocyte production after burn sepsis[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

[Target]

PGE2[1]

[References]

[1]. Maggi CA, et al. The effect of SC-19220, a prostaglandin antagonist, on the micturition reflex in rats. Eur J Pharmacol. 1988 Aug 2;152(3):273-9.

[2]. Santangelo S, Shoup M, Gamelli RL, Shankar R. Prostaglandin E2 receptor antagonist (SC-19220) treatment restores the balance to bone marrow myelopoiesis after burn sepsis. J Trauma. 2000 May;48(5):826-30; discussion 830-1.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₁₆H₁₄ClN₃O₃

[ Molecular Weight ]:
331.754

[ Exact Mass ]:
331.072357

[ PSA ]:
70.67000

[ LogP ]:
2.20

[ Index of Refraction ]:
1.624

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

The role of prostaglandin E and thromboxane-prostanoid receptors in the response to prostaglandin E2 in the aorta of Wistar Kyoto rats and spontaneously hypertensive rats.

Cardiovasc. Res. 78(1) , 130-8, (2008)

The present study examined the hypothesis that prostaglandin E2 (PGE2) through activation of prostaglandin E (EP) receptor contributes to endothelium-dependent contractions.Western blotting revealed t...

Prostanoid receptors involved in regulation of the beating rate of neonatal rat cardiomyocytes.

PLoS ONE 7(9) , e45273, (2012)

Although prostanoids are known to be involved in regulation of the spontaneous beating rate of cultured neonatal rat cardiomyocytes, the various subtypes of prostanoid receptors have not been investig...

Prostaglandin E₂ possesses different potencies in inducing Vascular Endothelial Growth Factor and Interleukin-8 production in COPD human lung fibroblasts.

Prostaglandins Leukot. Essent. Fatty Acids 106 , 11-Aug, (2016)

We studied the role of PGE2, its biosynthetic enzymes and its receptors, in regulating the functions of lung fibroblasts through the production of Vascular Endothelial Growth Factor (VEGF) and Interle...