Ceratotoxin-2

Names

[ CAS No. ]:
880885-98-3

[ Name ]:
Ceratotoxin-2

Biological Activity

[Description]:

Ceratotoxin-2 (CcoTx2) is a voltage-gated sodium channel blocker with IC50s of 8 nM and 88 nM against Nav1.2/β1 and Nav1.3/β1, respectively[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Research Areas >> Neurological Disease

[Target]

IC50: 8 nM (Nav1.2/β1), 88 nM (Nav1.3/β1), 400 nM (Nav1.4/β1), 407 nM (Nav1.1/β1), 1634 nM (Nav1.5/β1)[1]


[References]

[1]. Bosmans F, et al. Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Mol Pharmacol. 2006 Feb;69(2):419-29.  

Chemical & Physical Properties

[ Molecular Formula ]:
C177H260N52O49S6

[ Molecular Weight ]:
4092.67

Related Compounds

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